Article
Persistent infection of MT-4 cells by human immunodeficiency virus type 1 becomes increasingly likely with in vitro serial passage of wild-type but not nef mutant virus.
The Journal of general virology - 1 Sept 1994
Nishino Y, Nakaya T, Fujinaga K, Kishi M, Azuma I, Ikuta K
Abstract excerpt
Our previous studies have shown that human immunodeficiency virus type 1 (HIV-1), with mutations in accessory genes such as vif, vpr or vpu, can generate persistent infection of MT-4 cells, whereas infection by wild-type or nef mutant HIV-1 causes extensive cell death. The possibility of generati...
Topics
- Amino Acid Sequence
- Antigens, CD
- Base Sequence
- CD4 Antigens
- Cell Membrane
- Clone Cells
- DNA Primers
- Gene Products, env
- Genes, nef
- Genes, vif
- Genes, vpr
- Genes, vpu
- Giant Cells
- HIV Envelope Protein gp120
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Kinetics