Article
Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells.
Blood - 1 Apr 2003
Brenchley Jason M, Karandikar Nitin J, Betts Michael R, Ambrozak David R, Hill Brenna J, Crotty Laura E, Casazza Joseph P, Kuruppu Janaki, Migueles Stephen A, Connors Mark, Roederer Mario, Douek Daniel C, Koup Richard A
Abstract excerpt
Virus-specific CD8(+) T-cell responses play a pivotal role in limiting viral replication. Alterations in these responses, such as decreased cytolytic function, inappropriate maturation, and limited proliferative ability could reduce their ability to control viral replication. Here, we report on the capacity of HIV-specific CD8(+) T cells to secrete cytokines and proliferate in response to HIV antigen stimulation....
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