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Article

Cellular senescence: from growth arrest to immunogenic conversion.

Age (Dordrecht, Netherlands) - 1 Jan 2015

Burton D G A, Faragher R G A

Abstract excerpt

Cellular senescence was first reported in human fibroblasts as a state of stable in vitro growth arrest following extended culture. Since that initial observation, a variety of other phenotypic characteristics have been shown to co-associate with irreversible cell cycle exit in senescent fibroblasts. These include (1) a pro-inflammatory secretory response, (2) the up-regulation of immune ligands, (3) altered...

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Identifiers

PMID: 25787341
DOI: 10.1007/s11357-015-9764-2
PMCID: PMC4365077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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