Analysis of type II polyketide beta-ketoacyl synthase specificity in Streptomyces coelicolor A3(2) by trans complementation of actinorhodin synthase mutants.

doi:10.1128/jb.176.6.1801-1804.1994

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Article

Analysis of type II polyketide beta-ketoacyl synthase specificity in Streptomyces coelicolor A3(2) by trans complementation of actinorhodin synthase mutants.

Journal of bacteriology - 1 Mar 1994

Kim E S, Hopwood D A, Sherman D H

Abstract excerpt

Complementation of defined actinorhodin beta-ketoacyl synthase (KS) mutants by various other KS genes suggested that the ORF1-encoded KS may be relatively generalized in function, whereas the ORF2-encoded KS component may provide specificity in polyketide chain construction. Evidence for differen...

Topics

Animals
Genes, Bacterial
Genetic Complementation Test
Multienzyme Complexes
Mutation
Open Reading Frames
Rats
Streptomyces
Transformation, Genetic

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