Article
Roles of p53 mutation in cell line establishment and identification of the minimum transactivation and transform suppression domains.
European journal of cancer. Part B, Oral oncology - 1 Mar 1995
Hirano Y, Tsutsumi-Ishii Y, Tsuchida N
Abstract excerpt
The mutation of the p53 tumour suppressor gene is the most frequently recognised genetic alteration in human cancer. We recently showed that the frequency of p53 gene mutations in oral squamous cell carcinomas (SCCs) from which cell lines were established (group A) did not significantly differ from that in SCCs from which cell lines could not be established (group B), suggesting that the presence of a p53...
Topics
- Base Sequence
- Carcinoma, Squamous Cell
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Genes, Reporter
- Genes, p53
- Humans
- Molecular Sequence Data
- Mouth Neoplasms
- Mutation
- Plasmids