Article
Ineffectiveness of the presence of H-ras/p53 combination of mutations in squamous cell carcinoma cells to induce a conversion of a nontumorigenic to a tumorigenic phenotype.
Cell biology and toxicology - 1 Oct 1997
Lee H, Li D, Prior T, Casto B C, Weghorst C M, Shuler C F, Milo G E
Abstract excerpt
Human tumor cells have properties in vitro or in surrogate hosts that are distinct from those of normal cells, such as immortality, anchorage independence, and tumor formation in nude mice. However, different cells from individual tumors may exhibit some, but not all of these features. In previou...
Topics
- Animals
- Autoradiography
- Blotting, Northern
- Carcinoma, Squamous Cell
- DNA, Complementary
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Genes, ras
- Humans
- Male
- Methyl Methanesulfonate
- Methylnitronitrosoguanidine
- Mice
- Mice, Nude
- Mutation