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Article

Genetic alteration of the D2 domain abolishes von Willebrand factor multimerization and trafficking into storage.

Journal of thrombosis and haemostasis : JTH - 1 Apr 2009

Haberichter S L, Allmann A M, Jozwiak M A, Montgomery R R, Gill J C

Abstract excerpt

BACKGROUND: The large von Willebrand factor (VWF) propeptide (VWFpp) plays a critical role in the multimerization and regulated storage of the mature VWF protein. Although our laboratory and others have identified mutations in von Willebrand disease patients that disrupt VWF multimerization, little is known about the affect of mutations on the regulated storage of VWF. PATIENTS/METHODS: We identified a...

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Source

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Identifiers

PMID: 19192112
DOI: 10.1111/j.1538-7836.2009.03290.x
PMCID: PMC2745278

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic alteration of the D2 domain abolishes von Willebrand factor multimerization and trafficking into storage.PMID 19192112Read ↗

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