Article
Effects of the synthetic anti-oxidant, probucol, on the U937 monoblastoid cell line.
Atherosclerosis - 1 Feb 1993
Faulkner L, Aruoma O I, Brickell P M, Davies M J, Halliwell B, Woolf N, Katz D R
Abstract excerpt
Probucol is a clinically important drug that decreases plasma cholesterol in humans and has a marked anti-atherogenic effect in hyperlipidaemic Watanabe rabbits. The action of probucol in this animal model has been partly attributed to its anti-oxidant abilities. Probucol can decrease the oxidative modification of low-density lipoprotein and hence diminish its uptake by macrophages. In this paper, we have...
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