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Article

Prooxidant activity of melatonin promotes fas‐induced cell death in human leukemic Jurkat cells

1 Aug 2001

Abstract excerpt

The antioxidant activity of melatonin (MEL) has been considered to constitute part of its physiological as well as pharmacological effects. However, as described herein we found a profound prooxidant activity of micro- to millimolar concentrations of MEL in the human leukemic Jurkat cell line. This prooxidant effect was increased in glutathione-depleted cells and counteracted by antioxidants. As a consequence MEL...

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PMID: 11583113
DOI: 10.1016/s0014-5793(01)02680-1

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