Opposite sensitivity to the antiproliferative action of interferon-alpha and granulocyte-macrophage colony-stimulating factor in monoblastic U937 cells.

doi:10.1089/jir.1992.12.369

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Article

Opposite sensitivity to the antiproliferative action of interferon-alpha and granulocyte-macrophage colony-stimulating factor in monoblastic U937 cells.

Journal of interferon research - 1 Oct 1992

Kloke O, Moritz T, Kummer G, Hust H, Ross B, Seeber S, Niederle N

Abstract excerpt

Three variants of the human monoblastic cell line U937 with different degrees of sensitivity to the antiproliferative action of interferon-alpha (IFN-alpha were examined for phenotypic differences. The highly IFN-sensitive variant U937-V expressed twice as many IFN-alpha binding sites as both its IFN-alpha-resistant derivative U937-VR and the cell line U937 exhibiting a 20-fold reduction in IFN-alpha sensitivity...

Topics

2',5'-Oligoadenylate Synthetase
Cell Differentiation
Cell Division
Enzyme Induction
Granulocyte-Macrophage Colony-Stimulating Factor
Humans
Infant, Newborn
Interferon-alpha
Interferon-gamma
Leukemia, Monocytic, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Protein Binding

Receptors, Interferon

Sensitivity and Specificity

Tumor Cells, Cultured

Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 1431316
DOI: 10.1089/jir.1992.12.369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1431316-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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