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Article

Adenovirus early region 4 and viral DNA synthesis.

Virology - 1 Apr 1993

Bridge E, Medghalchi S, Ubol S, Leesong M, Ketner G

Abstract excerpt

Mutants of human adenovirus type 5 (Ad5) lacking early region 4 (E4) display a complex phenotype that includes a delay in the onset of viral DNA replication in low-multiplicity infections. Studies of viral DNA replication in vitro have not revealed a requirement for E4 products in DNA synthesis and, for most E4 mutants, defects in DNA replication are not apparent at high multiplicities of infection. The effects...

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Identifiers

PMID: 8460485
DOI: 10.1006/viro.1993.1188

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