Adenovirus early region 4 and viral DNA synthesis.

doi:10.1006/viro.1993.1188

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Article

Adenovirus early region 4 and viral DNA synthesis.

Virology - 1 Apr 1993

Bridge E, Medghalchi S, Ubol S, Leesong M, Ketner G

Abstract excerpt

Mutants of human adenovirus type 5 (Ad5) lacking early region 4 (E4) display a complex phenotype that includes a delay in the onset of viral DNA replication in low-multiplicity infections. Studies of viral DNA replication in vitro have not revealed a requirement for E4 products in DNA synthesis and, for most E4 mutants, defects in DNA replication are not apparent at high multiplicities of infection. The effects...

Topics

Adenoviruses, Human
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
DNA Replication
DNA, Viral
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Open Reading Frames
Phenotype
Protein Biosynthesis
Restriction Mapping
Vero Cells
Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 8460485
DOI: 10.1006/viro.1993.1188

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