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Article

Early region 4 modulates adenovirus DNA replication by two genetically separable mechanisms.

Virology - 15 Sept 1997

Medghalchi S, Padmanabhan R, Ketner G

Abstract excerpt

Three viral proteins, all products of early region 2 (E2), participate directly in adenovirus DNA replication. Three products of early region 4 (E4) also affect viral DNA synthesis: the product of E4 ORF4 inhibits viral DNA accumulation, while the products of E4 ORFs 3 and 6 antagonize that effec...

Topics

Adenovirus E2 Proteins
Adenovirus E4 Proteins
Adenoviruses, Human
Cell Nucleus
DNA Replication
Genotype
HeLa Cells
Humans
Mutagenesis
Open Reading Frames
RNA, Messenger
RNA, Viral
Transcription, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Proteins

Virus Replication

Source

Identifiers

PMID: 9299612
DOI: 10.1006/viro.1997.8737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9299612-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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