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Article

Early region 4 modulates adenovirus DNA replication by two genetically separable mechanisms.

Virology - 15 Sept 1997

Medghalchi S, Padmanabhan R, Ketner G

Abstract excerpt

Three viral proteins, all products of early region 2 (E2), participate directly in adenovirus DNA replication. Three products of early region 4 (E4) also affect viral DNA synthesis: the product of E4 ORF4 inhibits viral DNA accumulation, while the products of E4 ORFs 3 and 6 antagonize that effect of ORF4 expression. Because no E4 products are required for DNA synthesis, these proteins probably act indirectly....

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Identifiers

PMID: 9299612
DOI: 10.1006/viro.1997.8737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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