Article
Abnormal regulation of interferon-gamma, interleukin-12, and tumor necrosis factor-alpha in human interferon-gamma receptor 1 deficiency.
The Journal of infectious diseases - 1 Oct 1998
Holland S M, Dorman S E, Kwon A, Pitha-Rowe I F, Frucht D M, Gerstberger S M, Noel G J, Vesterhus P, Brown M R, Fleisher T A
Abstract excerpt
Mycobacterial infections are critically controlled by interferon-gamma (IFN-gamma) and the cellular responses it elaborates, as shown by patients with mutations in the IFN-gamma receptor ligand-binding chain (IFN-gamma R1) who have disseminated nontuberculous mycobacterial infections. The immunol...
Topics
- Amino Acid Sequence
- Child, Preschool
- Genes, Recessive
- Heterozygote
- Humans
- Interferon-gamma
- Interleukin-12
- Leukocytes, Mononuclear
- Male
- Molecular Sequence Data
- Mutation