Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abnormal regulation of interferon-gamma, interleukin-12, and tumor necrosis factor-alpha in human interferon-gamma receptor 1 deficiency.

The Journal of infectious diseases - 1 Oct 1998

Holland S M, Dorman S E, Kwon A, Pitha-Rowe I F, Frucht D M, Gerstberger S M, Noel G J, Vesterhus P, Brown M R, Fleisher T A

Abstract excerpt

Mycobacterial infections are critically controlled by interferon-gamma (IFN-gamma) and the cellular responses it elaborates, as shown by patients with mutations in the IFN-gamma receptor ligand-binding chain (IFN-gamma R1) who have disseminated nontuberculous mycobacterial infections. The immunologic sequelae of IFN-gamma R1 deficiency were characterized in 2 unrelated patients from the Indian subcontinent with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to TNF gene

Share to Genes, Recessive

Share to Heterozygote

Share to Molecular Sequence Data

Share to Mutation

Share to Pedigree

Source

Identifiers

PMID: 9806040
DOI: 10.1086/515670

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormal regulation of interferon-gamma, interleukin-12, and tumor necrosis factor-alpha in human interferon-gamma receptor 1 deficiency.PMID 9806040Read ↗

Defects in the interferon-gamma and interleukin-12 pathways.Semantic proximity Read ↗

Human interferon-gamma-mediated immunity is a genetically controlled continuous trait that determines the outcome of mycobacterial invasion.Semantic proximity Read ↗

Human host genetic factors in nontuberculous mycobacterial infection: lessons from single gene disorders affecting innate and adaptive immunity and lessons from molecular defects in interferon-gamma-dependent signaling.Semantic proximity Read ↗

Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense.Semantic proximity Read ↗

Impaired interferon gamma-mediated immunity and susceptibility to mycobacterial infection in childhood.Semantic proximity Read ↗

Human deficiencies in type 1 cytokine receptors reveal the essential role of type 1 cytokines in immunity to intracellular bacteria.Semantic proximity Read ↗

Inborn errors of IL-12/23- and IFN-gamma-mediated immunity: molecular, cellular, and clinical features.Semantic proximity Read ↗

Interferon-gamma and interleukin-12 pathway defects and human disease.Semantic proximity Read ↗

Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency.Semantic proximity Read ↗

Partial interferon-gamma receptor signaling chain deficiency in a patient with bacille Calmette-Guérin and Mycobacterium abscessus infection.Semantic proximity Read ↗

Normal expression of IFN-gammaR in four patients with uncommon mycobacterial infection phenotypes.Semantic proximity Read ↗

Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.