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Article

Primary Infection with Zidovudine-Resistant Human Immunodeficiency Virus Type 1

22 Apr 1993

Abstract excerpt

Strains of human immunodeficiency virus type 1 (HIV-1) with reduced sensitivity to zidovudine have been isolated from patients treated with this drug for six months or more1. Resistance to zidovudine is associated with late-stage disease, low CD4 lymphocyte counts, longer antiretroviral therapy, and specific mutations in the reverse transcriptase gene of HIV-12,3. The clinical importance of infections with...

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PMID: 8455683
DOI: 10.1056/nejm199304223281605

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