Article
Absence of activating mutations of the RAF1 protooncogene in human lung cancer.
Biological chemistry Hoppe-Seyler - 1 Oct 1994
Miwa W, Yasuda J, Yashima K, Makino R, Sekiya T
Abstract excerpt
Recently, the RAF protein has been demonstrated to be a direct effector of RAS protein in a RAS-mediated signal transduction pathway. Activations of the RAF1 gene by small mutations, such as point mutations in the kinase domain and a tetrapeptide insertion into conserved region 2, have been sugge...
Topics
- Base Sequence
- Codon
- DNA, Neoplasm
- Genes, ras
- Humans
- Lung Neoplasms
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-raf