Article
Absence of activating mutations of the RAF1 protooncogene in human lung cancer.
Biological chemistry Hoppe-Seyler - 1 Oct 1994
Miwa W, Yasuda J, Yashima K, Makino R, Sekiya T
Abstract excerpt
Recently, the RAF protein has been demonstrated to be a direct effector of RAS protein in a RAS-mediated signal transduction pathway. Activations of the RAF1 gene by small mutations, such as point mutations in the kinase domain and a tetrapeptide insertion into conserved region 2, have been suggested from analyses of chemically induced lung cancers in mice and by site-directed mutagenesis. We investigated the...
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