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Article

Substituted purines elicit differential cytokinetic, molecular and phenotypic effects in HL-60 cells.

Experimental hematology - 1 Mar 1993

Davidoff A N, Mendelow B V

Abstract excerpt

This study investigated and compared the cytokinetic, phenotypic and molecular effects elicited in HL-60 human leukemic cells by low doses (0.6 microM) of 3 closely related, substituted purines, puromycin (PM), puromycin aminonucleoside (PAN) and 6-dimethylaminopurine (6-DMAP). PM, but not 6-DMAP or PAN, inhibited [14C]leucine incorporation, induced a time-related cytotoxic effect, a G2-arrest, a...

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PMID: 8440343

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