Substituted purines elicit differential cytokinetic, molecular and phenotypic effects in HL-60 cells.

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Article

Substituted purines elicit differential cytokinetic, molecular and phenotypic effects in HL-60 cells.

Experimental hematology - 1 Mar 1993

Davidoff A N, Mendelow B V

Abstract excerpt

This study investigated and compared the cytokinetic, phenotypic and molecular effects elicited in HL-60 human leukemic cells by low doses (0.6 microM) of 3 closely related, substituted purines, puromycin (PM), puromycin aminonucleoside (PAN) and 6-dimethylaminopurine (6-DMAP). PM, but not 6-DMAP...

Topics

Adenine
Carbon Radioisotopes
Cell Cycle
DNA, Neoplasm
Dose-Response Relationship, Drug
Down-Regulation
Flow Cytometry
Humans
Kinetics
Leucine
Leukemia, Promyelocytic, Acute
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-myc

Purines

Puromycin

Puromycin Aminonucleoside

RNA, Messenger

Time Factors

Source

Open in PubMed

Identifiers

PMID: 8440343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8440343-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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