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Article

Opposite effects of cell differentiation and apoptosis on Ap<sub>3</sub>A/Ap<sub>4</sub>A ratio in human cell cultures

29 Sept 1997

Abstract excerpt

The biological role of diadenosine oligophosphates (DAOP) remains obscure in spite of numerous attempts to solve this enigma. It is known that Ap3A contrary to Ap4A accumulates in human cultured cells treated with interferons (IFNs) alpha or gamma. Since IFNs are considered as antiproliferative regulators, we assumed that different cell status may be associated with varying intracellular levels of DAOP....

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PMID: 9350987
DOI: 10.1016/s0014-5793(97)01086-7

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