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Article

Induction of apoptosis and inhibition of signalling pathways by alkylated purines.

Mutagenesis - 1 Jul 2000

Bonatti S, Pigullo S, Simili M, Abbondandolo A

Abstract excerpt

Addition of growth factors such as EGF and insulin to serum-starved G(0) Chinese hamster fibroblast cells results in activation of the phosphatidylinositol 3-kinase (PI3-K)/p70 S6 kinase (p70(S6K)) pathway and the ras-raf mitogen-activated kinase (MAPK) pathway. Activation of these pathways is usually associated with protection of cells from apoptosis. We have studied the effect of three alkylpurines,...

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Source

Identifiers

PMID: 10887217
DOI: 10.1093/mutage/15.4.361

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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