Article
Increased survival of L1210 leukemic mice by prevention of the utilization of extracellular polyamines. Studies using a polyamine-uptake mutant, antibiotics and a polyamine-deficient diet.
Cancer letters - 14 Sept 1992
Ask A, Persson L, Heby O
Abstract excerpt
When L1210 leukemia cells are inhibited in their polyamine synthesis by treatment with alpha-difluoromethylornithine (DFMO), their growth in culture is strongly suppressed. In striking contrast, the survival of L1210 leukemic mice is only marginally prolonged by DFMO treatment. This inconsistency...
Topics
- Animals
- Anti-Bacterial Agents
- Biological Transport
- Carbon Radioisotopes
- Drug Resistance
- Eflornithine
- Extracellular Space
- Female
- Leukemia L1210
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mitoguazone
- Mutation
- Polyamines
- Sex Factors
- Spermidine