Article
The HIV-1 V3 domain on field isolates: participation in generation of escape virus in vivo and accessibility to neutralizing antibodies.
Archives of virology - 1 Jan 1995
Arendrup M, Akerblom L, Heegaard P M, Nielsen J O, Hansen J E
Abstract excerpt
The V3 domain is highly variable and induces HIV neutralizing antibodies (NA). Here we addressed the issues of 1) the participation of mutations in V3 in generation of neutralization resistant escape virus in vivo and 2) the applicability of synthetic V3 peptides corresponding to field isolates to induce neutralizing immune sera. Seven peptides corresponding to the V3 region of primary and escape virus from 3...
Topics
- Amino Acid Sequence
- Animals
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Immune Sera
- Immunization
- Molecular Sequence Data
- Mutation
- Neutralization Tests
- Peptide Fragments