Article
Association of mutations in V3/C3 domain with enhanced sensitivity of HIV-1 clade C primary envelopes to autologous broadly neutralizing plasma antibodies.
Retrovirology - 15 Jun 2016
Deshpande Suprit, Patil Shilpa, Kumar Rajesh, Shrivastava Tripti, Srikrishnan Aylur K, Murugavel Kailapuri G, Koff Wayne C, Chakrabarti Bimal K, Bhattacharya Jayanta
Abstract excerpt
BACKGROUND: Broadly neutralizing antibodies to HIV-1 elicited in infected individuals evolves through shifts in their molecular specificities to viral envelope (Env) in the disease course. Recently, we showed that resistance of circulating HIV-1 clade C to the autologous plasma obtained from one Indian elite neutralizer is associated with mutations in V1 loop. In the present study, we examined the genetic...
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