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Article

Functional complementation of major histocompatibility complex class II regulatory mutants by the purified X-box-binding protein RFX.

Molecular and cellular biology - 1 Oct 1994

Durand B, Kobr M, Reith W, Mach B

Abstract excerpt

Major histocompatibility complex (MHC) class II deficiency, or bare lymphocyte syndrome (BLS), is a disease of gene regulation. Patients with BLS have been classified into at least three complementation groups (A, B, and C) believed to correspond to three distinct MHC class II regulatory genes. The elucidation of the molecular basis for this disease will thus clarify the mechanisms controlling the complex...

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Identifiers

PMID: 7935401
DOI: 10.1128/mcb.14.10.6839-6847.1994
PMCID: PMC359214

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional complementation of major histocompatibility complex class II regulatory mutants by the purified X-box-binding protein RFX.PMID 7935401Read ↗

A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome).Semantic proximity Read ↗

RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency.Semantic proximity Read ↗

Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class II transactivator in RFX-B-deficient cells.Semantic proximity Read ↗

Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex.Semantic proximity Read ↗

Analysis of the defect in IFN-gamma induction of MHC class II genes in G1B cells: identification of a novel and functionally critical leucine-rich motif (62-LYLYLQL-68) in the regulatory factor X 5 transcription factor.Semantic proximity Read ↗

Regulatory factor X, a bare lymphocyte syndrome transcription factor, is a multimeric phosphoprotein complexSemantic proximity Read ↗

Conserved residues of the bare lymphocyte syndrome transcription factor RFXAP determine coordinate MHC class II expression.Semantic proximity Read ↗

A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients.Semantic proximity Read ↗

The Bare Lymphocyte Syndrome and the Regulation of MHC ExpressionSemantic proximity Read ↗

Dissection of functional NF-Y-RFX cooperative interactions on the MHC class II Ea promoter.Semantic proximity Read ↗

Mutation of RFXAP, a regulator of MHC class II genes, in primary MHC class II deficiency.Semantic proximity Read ↗

The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters.Semantic proximity Read ↗

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