Article
Functional complementation of major histocompatibility complex class II regulatory mutants by the purified X-box-binding protein RFX.
Molecular and cellular biology - 1 Oct 1994
Durand B, Kobr M, Reith W, Mach B
Abstract excerpt
Major histocompatibility complex (MHC) class II deficiency, or bare lymphocyte syndrome (BLS), is a disease of gene regulation. Patients with BLS have been classified into at least three complementation groups (A, B, and C) believed to correspond to three distinct MHC class II regulatory genes. T...
Topics
- Base Sequence
- Cell Nucleus
- Cell-Free System
- DNA-Binding Proteins
- Gene Expression Regulation
- HLA-DR Antigens
- HLA-DR alpha-Chains
- Humans
- Immunologic Deficiency Syndromes
- Lymphocytes
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Protein Binding
- Regulatory Factor X Transcription Factors
- Subcellular Fractions
- Transcription Factors
- Transcription, Genetic