Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of sialyl-Tn epitopes on beta1 integrin alters epithelial cell phenotype, proliferation and haptotaxis.

Journal of cell science - 1 Oct 2004

Clément Monique, Rocher Jézabel, Loirand Gervaise, Le Pendu Jacques

Abstract excerpt

Sialyl-Tn (STn) is a tumor-associated carbohydrate antigen overexpressed in various carcinomas. To obtain its expression, murine carcinoma cells were transfected with the cDNA encoding ST6GalNAc I, a glycosyltransferase that acts exclusively on O-glycans. Overexpression of this enzyme led to the expected expression of cell surface STn epitopes. Surprisingly, the transfectants (STn+ cells) presented dramatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Tumor-Associated, Carbohydrate
Share to Chemotaxis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fibronectins

Share to Hyaluronic Acid

Share to Integrin beta1

Share to Integrins

Share to Sialyltransferases

Share to Wound Healing

Source

Identifiers

PMID: 15383613
DOI: 10.1242/jcs.01350

Genes

TAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of sialyl-Tn epitopes on beta1 integrin alters epithelial cell phenotype, proliferation and haptotaxis.PMID 15383613Read ↗

Biological significance of cancer-associated sialyl-Tn antigen: modulation of malignant phenotype in gastric carcinoma cells.Semantic proximity Read ↗

α2-6–Linked Sialic Acids on N-Glycans Modulate Carcinoma Differentiation <i>In vivo</i>Semantic proximity Read ↗

The Role of Sialyl-Tn in CancerSemantic proximity Read ↗

Regulation of the metastatic cell phenotype by sialylated glycans.Semantic proximity Read ↗

β-Galactoside α2,6-sialyltranferase 1 promotes transforming growth factor-β-mediated epithelial-mesenchymal transition.Semantic proximity Read ↗

Reversible Disruption of Cell-Matrix and Cell-Cell Interactions by Overexpression of Sialomucin ComplexSemantic proximity Read ↗

Phenotypic changes induced by expression of beta-galactoside alpha2,6 sialyltransferase I in the human colon cancer cell line SW948.Semantic proximity Read ↗

The cellular microenvironment and cell adhesion: a role for O-glycosylation.Semantic proximity Read ↗

Expression of ST6GalNAc1 and sialyl-Tn antigen enhances endometrial receptivitySemantic proximity Read ↗

Rho GTPase Rac1: molecular switch within the galectin network and for N-glycan α2,6-sialylation/O-glycan core 1 sialylation in colon cancer in vitro.Semantic proximity Read ↗

Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.Semantic proximity Read ↗

Sialylation and malignant potential in tumour cell glycosylation mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.