Article
Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1993
Newell K, Franchi A, Pouysségur J, Tannock I
Abstract excerpt
Solid tumors have been observed to develop an acidic extracellular environment, which is believed to occur as a result of lactic acid accumulation produced during aerobic and anaerobic glycolysis. Experiments using glycolysis-deficient ras-transfected Chinese hamster lung fibroblasts have been performed to test the hypothesis that lactic acid production within solid tumors is responsible for the development of...
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