Lactic acidosis switches cancer cells from aerobic glycolysis back to dominant oxidative phosphorylation.

Abstract excerpt

While transformation of normal cells to cancer cells is accompanied with a switch from oxidative phosphorylation (OXPHOS) to aerobic glycolysis, it is interesting to ask if cancer cells can revert from Warburg effect to OXPHOS. Our previous works suggested that cancer cells reverted to OXPHOS, when they were exposed to lactic acidosis, a common factor in tumor environment. However, the conclusion cannot be drawn...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Acidosis, Lactic
• Share to Aerobiosis
• Share to Glycolysis