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Article

Characterization of K562 cells following introduction of a mutant N-ras gene.

Leukemia research - 1 Jan 1993

Thorn J T, Todd A V, Croaker G M, Iland H J

Abstract excerpt

A mutant human N-ras gene (codon 61, C to A substitution) was electroporated into the human leukemic cell line K562, originally derived from a patient with chronic myeloid leukemia (CML) in blast crisis. Despite confirmation of mutant N-ras gene integration and expression, mutant transfected cells exhibited no growth advantage when characterized in suspension cultures and clonogenic assays, and serum deprivation...

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Identifiers

PMID: 8429676
DOI: 10.1016/0145-2126(93)90137-a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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