Article
Synthesis of normal and variant human hypoxanthine-guanine phosphoribosyltransferase in Escherichia coli.
Gene - 30 Jan 1993
Davidson B L, Brown J E, Weber C H, Palella T D, Roessler B J
Abstract excerpt
Naturally occurring mutations in hypoxanthine-guanine phosphoribosyltransferase (HPRT) have been identified by amino acid sequencing, cDNA cloning, and direct nucleotide sequencing of PCR-amplified transcripts. To determine the effect these mutations have on the catalytic properties of the molecule, knowledge of the three-dimensional structure of HPRT is required. A prerequisite for this, however, is the...
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