The innate immune response to adjuvants dictates the adaptive immune response to autoantigens.

doi:10.1097/NEN.0b013e31817713cc

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Article

The innate immune response to adjuvants dictates the adaptive immune response to autoantigens.

Journal of neuropathology and experimental neurology - 1 Jun 2008

Staykova Maria A, Liñares David, Fordham Susan A, Paridaen Judith T, Willenborg David O

Abstract excerpt

To elucidate the role of innate immunity in susceptibility to the animal model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE), we induced EAE by immunization with spinal cord homogenate (SCH) plus complete Freund adjuvant or carbonyl iron in 3 inbred rat strains. Lewis are considered "susceptible," PVG/c-Rt7a (PVG) as "semisusceptible," and Brown Norway (BN) as "resistant" to EAE....

Topics

Adjuvants, Immunologic
Animals
Autoantigens
Encephalomyelitis, Autoimmune, Experimental
Flow Cytometry
Freund's Adjuvant
Genetic Predisposition to Disease
Immunity, Innate
Immunohistochemistry
Indoleamine-Pyrrole 2,3,-Dioxygenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interferon-gamma

Iron Compounds

Macrophage Activation

Nitric Oxide

Rats

Reverse Transcriptase Polymerase Chain Reaction

Spinal Cord

T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 18520773
DOI: 10.1097/NEN.0b013e31817713cc

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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