Article
Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms.
The New England journal of medicine - 14 May 1992
Malkin D, Jolly K W, Barbier N, Look A T, Friend S H, Gebhardt M C, Andersen T I, Børresen A L, Li F P, Garber J
Abstract excerpt
BACKGROUND: Acquired mutations in the p53 tumor-suppressor gene have been detected in several human cancers, including colon, breast, and lung cancer. Inherited mutations (transmitted through the germline) of this gene can underlie the Li-Fraumeni syndrome, a rare familial association of breast cancer in young women, childhood sarcomas, and other malignant neoplasms. We investigated the possibility that p53...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.