Article
Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms.
The New England journal of medicine - 14 May 1992
Malkin D, Jolly K W, Barbier N, Look A T, Friend S H, Gebhardt M C, Andersen T I, Børresen A L, Li F P, Garber J
Abstract excerpt
BACKGROUND: Acquired mutations in the p53 tumor-suppressor gene have been detected in several human cancers, including colon, breast, and lung cancer. Inherited mutations (transmitted through the germline) of this gene can underlie the Li-Fraumeni syndrome, a rare familial association of breast cancer in young women, childhood sarcomas, and other malignant neoplasms. We investigated the possibility that p53...
Topics
- Adolescent
- Adult
- Amino Acid Sequence
- Child
- DNA
- Exons
- Female
- Genes, p53
- Humans
- Infant
- Male
- Molecular Sequence Data