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Article

Multiple regulation of ornithine decarboxylase in enzyme-overproducing cells.

The Biochemical journal - 15 Jan 1993

Kameji T, Hayashi S, Hoshino K, Kakinuma Y, Igarashi K

Abstract excerpt

We have isolated from mouse FM3A cells a variant cell line, termed EXOD-1, that overproduces ornithine decarboxylase (ODC). The cells were resistant to alpha-difluoromethylornithine, an irreversible inhibitor of the enzyme, and produced the enzyme protein to the extent of approx. 3-6% of total cytosolic protein. The rate of ODC synthesis in this cell line accounted for 25-50% of the rate of total protein...

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Identifiers

PMID: 8424799
DOI: 10.1042/bj2890581
PMCID: PMC1132208

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