Article
Multiple regulation of ornithine decarboxylase in enzyme-overproducing cells.
The Biochemical journal - 15 Jan 1993
Kameji T, Hayashi S, Hoshino K, Kakinuma Y, Igarashi K
Abstract excerpt
We have isolated from mouse FM3A cells a variant cell line, termed EXOD-1, that overproduces ornithine decarboxylase (ODC). The cells were resistant to alpha-difluoromethylornithine, an irreversible inhibitor of the enzyme, and produced the enzyme protein to the extent of approx. 3-6% of total cy...
Topics
- Animals
- Cell Division
- Cell Line
- Drug Resistance
- Eflornithine
- Genetic Variation
- Kinetics
- Mice
- Molecular Weight
- Ornithine Decarboxylase
- Polyamines
- RNA, Messenger
- Time Factors