Article
The role of interleukin-6 in mucosal IgA antibody responses in vivo.
Science (New York, N.Y.) - 22 Apr 1994
Ramsay A J, Husband A J, Ramshaw I A, Bao S, Matthaei K I, Koehler G, Kopf M
Abstract excerpt
In mice with targeted disruption of the gene that encodes interleukin-6 (IL-6), greatly reduced numbers of immunoglobulin A (IgA)-producing cells were observed at mucosae and grossly deficient local antibody responses were recorded after mucosal challenge with either ovalbumin or vaccinia virus....
Topics
- Animals
- Immunoglobulin A
- Immunoglobulin G
- Interleukin-6
- Intestinal Mucosa
- Lung
- Lymph Nodes
- Mesentery
- Mice
- Mucous Membrane
- Mutation
- Ovalbumin
- Plasma Cells
- Transfection
- Vaccinia
- Vaccinia virus