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Article

A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jan 1993

Epstein D J, Vogan K J, Trasler D G, Gros P

Abstract excerpt

The splotch (Sp) mouse mutant displays defects in neural tube closure in the form of exencephaly and spina bifida. Recently, mutations in the Pax-3 gene have been described in the radiation-induced Spr and Sp2H alleles. This led us to examine the integrity of the Pax-3 gene and its cellular mRNA transcript in the original, spontaneously arising Sp allele. A complex mutation in the Pax-3 gene including an A-->T...

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Identifiers

PMID: 8421686
DOI: 10.1073/pnas.90.2.532
PMCID: PMC45697

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A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant.PMID 8421686Read ↗

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