Article
Production of DNP-specific/class I MHC-restricted suppressor molecules is linked to the expression of T cell receptor alpha- and beta-chain genes.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 1993
Fairchild R L, Palmer E, Moorhead J W
Abstract excerpt
The hapten/class I MHC-specific soluble immunoregulatory molecules produced by CD8+T cells from dinitrobenzene sulfonate-primed mice express the binding specificity and serologic determinants of alpha/beta TCR. To examine the genes used to encode these soluble immunoregulatory molecules, we utili...
Topics
- Animals
- Clone Cells
- Dinitrophenols
- Gene Expression
- Genes, Immunoglobulin
- Histocompatibility Antigens Class I
- Immunoglobulin Variable Region
- Mice
- Mice, Inbred BALB C
- Mutation
- Receptors, Antigen, T-Cell, alpha-beta
- Sequence Deletion
- Suppressor Factors, Immunologic
- T-Lymphocytes, Regulatory