Article
Inserting the Ftz homeodomain into engrailed creates a dominant transcriptional repressor that specifically turns off Ftz target genes in vivo.
Development (Cambridge, England) - 1 Jun 1995
John A, Smith S T, Jaynes J B
Abstract excerpt
The Engrailed homeodomain protein is an 'active' or dominant transcriptional repressor in cultured cells. In contrast, the Fushi Tarazu homeodomain protein is an activator, both in cultured cells and in Drosophila embryos, where it activates several known target genes, including its own gene. Thi...
Topics
- Animals
- Drosophila
- Drosophila Proteins
- Enhancer Elements, Genetic
- Fushi Tarazu Transcription Factors
- Gene Expression Regulation, Developmental
- Gene Transfer Techniques
- Genes, Homeobox
- Homeodomain Proteins
- Insect Hormones
- Morphogenesis
- Phenotype
- Recombinant Proteins
- Regulatory Sequences, Nucleic Acid
- Repressor Proteins
- Transcription Factors