Three Mechanisms Are Involved in Glucocorticoid Receptor Autoregulation in a Human T-Lymphoblast Cell Line

doi:10.1021/bi049458u

Article

Three Mechanisms Are Involved in Glucocorticoid Receptor Autoregulation in a Human T-Lymphoblast Cell Line

1 Aug 2004

Abstract excerpt

Glucocorticoids up-regulate the glucocorticoid receptor (GR) in the human T-lymphoblast cell line CEM-C7. One mechanism for the up-regulation of the GR protein is the well-known up-regulation of GR transcripts. We have investigated the effect of other factors on the up-regulation. At least three promoters (1A, 1B, and 1C) exist, which give rise to GR transcripts with different exon 1 sequences. Transcripts with...

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