Article
Identification of a glucocorticoid response element in the rat beta2-adrenergic receptor gene.
Molecular pharmacology - 1 Dec 1998
Cornett L E, Hiller F C, Jacobi S E, Cao W, McGraw D W
Abstract excerpt
Regulation of beta2-adrenergic receptor (beta2AR) levels by glucocorticoids is a physiologically important mechanism for altering beta2AR responsiveness. Glucocorticoids increase beta2AR density by increasing the rate of beta2AR gene transcription, but the cis-elements involved have not been well characterized. We now show that one of six potential glucocorticoid response elements (GREs) in the 5'-flanking region...
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