Article
A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus.
The Journal of cell biology - 1 Nov 1994
Benton B M, Zang J H, Thorner J
Abstract excerpt
The gene (FPR3) encoding a novel type of peptidylpropyl-cis-trans-isomerase (PPIase) was isolated during a search for previously unidentified nuclear proteins in Saccharomyces cerevisiae. PPIases are thought to act in conjunction with protein chaperones because they accelerate the rate of conform...
Topics
- Amino Acid Isomerases
- Amino Acid Sequence
- Base Sequence
- Carrier Proteins
- Cell Nucleolus
- Cloning, Molecular
- DNA, Fungal
- Escherichia coli
- Genes, Fungal
- Genotype
- Heat-Shock Proteins
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Oligodeoxyribonucleotides
- Peptidylprolyl Isomerase