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Article

Differentiation of Pseudomonas aeruginosa into the alginate-producing form: inactivation of mucB causes conversion to mucoidy.

Molecular microbiology - 1 Aug 1993

Martin D W, Schurr M J, Mudd M H, Deretic V

Abstract excerpt

Mucoidy in Pseudomonas aeruginosa is a critical virulence factor associated with chronic respiratory infections in cystic fibrosis. A cluster of three tightly linked genes, algU, mucA and mucB located at 67.5 min, controls development of mucoid phenotype. This locus is allelic with a group of mutations (muc) associated with conversion into constitutively mucoid forms. One of the genes previously characterized in...

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PMID: 8412698
DOI: 10.1111/j.1365-2958.1993.tb01711.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Differentiation of Pseudomonas aeruginosa into the alginate-producing form: inactivation of mucB causes conversion to mucoidy.PMID 8412698Read ↗

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Analysis of promoters controlled by the putative sigma factor AlgU regulating conversion to mucoidy in Pseudomonas aeruginosa: relationship to sigma E and stress response.Semantic proximity Read ↗

Sigma factor-anti-sigma factor interaction in alginate synthesis: inhibition of AlgT by MucA.Semantic proximity Read ↗

Mutations in the mucA gene of Pseudomonas aeruginosa promote disease exacerbation.Semantic proximity Read ↗

Two distinct loci affecting conversion to mucoidy in Pseudomonas aeruginosa in cystic fibrosis encode homologs of the serine protease HtrA.Semantic proximity Read ↗

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