Article
Differentiation of Pseudomonas aeruginosa into the alginate-producing form: inactivation of mucB causes conversion to mucoidy.
Molecular microbiology - 1 Aug 1993
Martin D W, Schurr M J, Mudd M H, Deretic V
Abstract excerpt
Mucoidy in Pseudomonas aeruginosa is a critical virulence factor associated with chronic respiratory infections in cystic fibrosis. A cluster of three tightly linked genes, algU, mucA and mucB located at 67.5 min, controls development of mucoid phenotype. This locus is allelic with a group of mut...
Topics
- Alginates
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Cystic Fibrosis
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Molecular Sequence Data
- Morphogenesis
- Multigene Family
- Mutagenesis, Insertional
- Phenotype
- Promoter Regions, Genetic
- Pseudomonas aeruginosa
- Sequence Analysis, DNA
- Sigma Factor
- Virulence