Mucoid Pseudomonas aeruginosa and cystic fibrosis: the role of mutations in muc loci.

doi:10.1111/j.1574-6968.1992.tb14059.x

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Article

Mucoid Pseudomonas aeruginosa and cystic fibrosis: the role of mutations in muc loci.

FEMS microbiology letters - 15 Dec 1992

Govan J R, Martin D W, Deretic V P

Abstract excerpt

Mucoid alginate-producing mutants of Pseudomonas aeruginosa are major pathogens in debilitating chronic pulmonary infections in patients with cystic fibrosis. The mucoid phenotype results from alginate biosynthesis whose genes are arranged in at least three chromosomal loci. Structural genes are...

Topics

Alginates
Cystic Fibrosis
Genes, Bacterial
Glucuronic Acid
Hexuronic Acids
Humans
Mutation
Pseudomonas aeruginosa

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