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Article

Mutational screening of the Wilms's tumour gene, WT1, in males with genital abnormalities.

Journal of medical genetics - 1 Sept 1993

Clarkson P A, Davies H R, Williams D M, Chaudhary R, Hughes I A, Patterson M N

Abstract excerpt

Several lines of evidence suggest that the Wilms's tumour susceptibility gene, WT1, has an important role in genital as well as kidney development. WT1 is expressed in developing kidney and genital tissues. Furthermore, mutations in WT1 have been detected in patients with the Denys-Drash syndrome (DDS), which is characterised by nephropathy, genital abnormalities, and Wilms's tumour. It is possible that WT1...

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Identifiers

PMID: 8411073
DOI: 10.1136/jmg.30.9.767
PMCID: PMC1016535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutational screening of the Wilms's tumour gene, WT1, in males with genital abnormalities.PMID 8411073Read ↗

Analysis of the Wilms' tumor suppressor gene (WT1) in patients 46,XY disorders of sex development.Semantic proximity Read ↗

WT1 Haploinsufficiency Supports Milder Renal Manifestation in Two Patients with Denys-Drash Syndrome.Semantic proximity Read ↗

A familial WT1 mutation associated with incomplete Denys-Drash syndrome.Semantic proximity Read ↗

Fine structure analysis of the WT1 gene in sporadic Wilms tumors.Semantic proximity Read ↗

WT1 gene mutations in three girls with nephrotic syndrome.Semantic proximity Read ↗

A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome.Semantic proximity Read ↗

Pulmonary dysplasia, Denys-Drash syndrome and Wilms tumor 1 gene mutation in twins.Semantic proximity Read ↗

Evidence that WT1 mutations in Denys-Drash syndrome patients may act in a dominant-negative fashion.Semantic proximity Read ↗

WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour.Semantic proximity Read ↗

Frasier syndrome, part of the Denys Drash continuum or simply a WT1 gene associated disorder of intersex and nephropathy?Semantic proximity Read ↗

WT1 Gene Mutation, p.R462W, in a 46,XY DSD Patient from Egypt with Gonadoblastoma and Review of the Literature.Semantic proximity Read ↗

Identification of mutations in the WT1 gene in tumours from patients with the WAGR syndrome.Semantic proximity Read ↗

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