Article
Pulmonary dysplasia, Denys-Drash syndrome and Wilms tumor 1 gene mutation in twins.
Pediatric nephrology (Berlin, Germany) - 1 Mar 2001
Dharnidharka V R, Ruteshouser E C, Rosen S, Kozakewich H, Harris H W, Herrin J T, Huff V
Abstract excerpt
While a genetic basis for the association of developmental lung and kidney defects has been suspected, the involvement of specific genes in this process is under active investigation. We report such a possible genetic linkage present in identical twins with a mutant Wilms tumor (WT1) gene. Twin girls, born at 35 weeks gestation, manifested symptoms of congenital nephrotic syndrome, renal failure, and severe...
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