Article
Reversal of cisplatin resistance in human ovarian cancer cell lines by a c-jun antisense oligodeoxynucleotide (ISIS 10582): evidence for the role of transcription factor overexpression in determining resistant phenotype.
Biochemical pharmacology - 1 May 2002
Pan Bin, Yao Kang Shen, Monia Brett P, Dean Nicholas M, McKay Robert A, Hamilton Thomas C, O'Dwyer Peter J
Abstract excerpt
Human ovarian cancer cell lines derived from A2780 by stepwise exposure to increasing cisplatin concentrations show progressive resistance to cisplatin. Previous studies have shown increased cellular glutathione and elevated steady-state expression of gamma-glutamylcysteine synthetase (gamma-GCS) and of the transcription factor c-Jun, all in proportion to the level of resistance in the resistant cells. We...
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