Allelic variation of reporter gene activation by the HRAS1 minisatellite.

Abstract excerpt

We have recently shown that constitutively expressed members of the rel/NF-kappa B family of transcription factors bind the HRAS1 minisatellite, VTRHRAS1. We now report that, like other NF-kappa B binding sites, VTRHRAS1 displays pleiotropic transcriptional regulatory activity that is promoter- and cell-type-specific. Both enhancement and suppression are restricted to the human bladder carcinoma cell line EJ, in...

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