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Article

An association between the risk of cancer and mutations in the HRAS1 minisatellite locus.

The New England journal of medicine - 19 Aug 1993

Krontiris T G, Devlin B, Karp D D, Robert N J, Risch N

Abstract excerpt

BACKGROUND: The role of mutations in protooncogenes and their regulatory sequences in the pathogenesis of cancer is under close scrutiny. Minisatellites are unstable repetitive sequences of DNA that are present throughout the human genome. The highly polymorphic HRAS1 minisatellite locus just downstream from the protooncogene H-ras-1 consists of four common progenitor alleles and several dozen rare alleles, which...

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PMID: 8336750
DOI: 10.1056/NEJM199308193290801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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