Potentiation of a tumor cell susceptibility to autologous CTL killing by restoration of wild-type p53 function.

doi:10.4049/jimmunol.170.12.5919

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Article

Potentiation of a tumor cell susceptibility to autologous CTL killing by restoration of wild-type p53 function.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2003

Thiery Jérôme, Dorothée Guillaume, Haddada Hedi, Echchakir Hamid, Richon Catherine, Stancou Rodica, Vergnon Isabelle, Benard Jean, Mami-Chouaib Fathia, Chouaib Salem

Abstract excerpt

Inactivation of p53 has been implicated in many types of tumors particularly in non-small cell lung carcinoma, one of the most common cancers in which p53 mutation has been frequently identified. The aim of this study was to investigate the influence of p53 status on the regulation of tumor susceptibility to specific CTL-mediated cell death. For this purpose, we used a cytotoxic T lymphocyte clone, Heu127, able...

Topics

Adenoviridae
Apoptosis
Clone Cells
Cytotoxicity Tests, Immunologic
Cytotoxicity, Immunologic
Gene Silencing
Genetic Vectors
Granzymes
Humans
Immunity, Innate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Proteins

Receptors, Tumor Necrosis Factor

Serine Endopeptidases

T-Lymphocytes, Cytotoxic

Trans-Activators

Transcriptional Activation

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 12794118
DOI: 10.4049/jimmunol.170.12.5919

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