Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome replication and progeny virion production of herpes simplex virus type 1 mutants with temperature-sensitive lesions in the origin-binding protein.

Journal of virology - 1 Jun 2005

Schildgen Oliver, Gräper Sascha, Blümel Johannes, Matz Bertfried

Abstract excerpt

Genome replication of herpes simplex viruses (HSV) in cultured cells is thought to be started by the action of the virus-encoded origin-binding protein (OBP). In experiments using two HSV-1 mutants with temperature-sensitive lesions in the helicase domain of OBP, we demonstrated that this function is essential during the first 6 hours of the lytic cycle. Once DNA synthesis has started, this function is no longer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to Genome, Viral

Share to Herpesvirus 1, Human

Share to Vero Cells

Share to Viral Proteins

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 15890967
DOI: 10.1128/JVI.79.11.7273-7278.2005
PMCID: PMC1112152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome replication and progeny virion production of herpes simplex virus type 1 mutants with temperature-sensitive lesions in the origin-binding protein.PMID 15890967Read ↗

Inhibition of herpes simplex virus type 1 DNA replication by mutant forms of the origin-binding protein.Semantic proximity Read ↗

A novel conformation of the herpes simplex virus origin of DNA replication recognized by the origin binding protein.Semantic proximity Read ↗

Herpes simplex virus type 1 mutants for the origin-binding protein induce DNA amplification in the absence of viral replication.Semantic proximity Read ↗

Unwinding of a herpes simplex virus type 1 origin of replication (Ori(S)) by a complex of the viral origin binding protein and the single-stranded DNA binding protein.Semantic proximity Read ↗

Study on simian virus 40 DNA synthesis in herpes simplex virus-infected cells.Semantic proximity Read ↗

Herpes simplex virus type 1 C-terminal variants of the origin binding protein (OBP), OBPC-1 and OBPC-2, cooperatively regulate viral DNA levels in vitro, and OBPC-2 affects mortality in mice.Semantic proximity Read ↗

Origin activation requires both replicative and accessory helicases during T4 infection.Semantic proximity Read ↗

Characterization of the herpes simplex virus origin binding protein interaction with OriS.Semantic proximity Read ↗

Association of origin binding protein and single strand DNA-binding protein, ICP8, during herpes simplex virus type 1 DNA replication in vivo.Semantic proximity Read ↗

Kaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: cis-acting requirements for replication and ori-Lyt-associated RNA transcription.Semantic proximity Read ↗

Initiation of DNA replication within oriP is dispensable for stable replication of the latent Epstein-Barr virus chromosome after infection of established cell lines.Semantic proximity Read ↗

The Herpes Simplex Virus 2 UL21 Protein Is Essential for Virus PropagationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.