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Article

Altered myogenesis in Six1-deficient mice.

Development (Cambridge, England) - 1 May 2003

Laclef Christine, Hamard Ghislaine, Demignon Josiane, Souil Evelyne, Houbron Christophe, Maire Pascal

Abstract excerpt

Six homeoproteins are expressed in several tissues, including muscle, during vertebrate embryogenesis, suggesting that they may be involved in diverse differentiation processes. To determine the functions of the Six1 gene during myogenesis, we constructed Six1-deficient mice by replacing its first exon with the lacZ gene. Mice lacking Six1 die at birth because of severe rib malformations and show extensive muscle...

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Identifiers

PMID: 12668636
DOI: 10.1242/dev.00440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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