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Article

Mutations in the fourth EGF-like domain affect thrombomodulin-induced changes in the active site of thrombin.

Biochemistry - 14 Oct 2008

Koeppe Julia R, Beach Muneera A, Baerga-Ortiz Abel, Kerns S Jordan, Komives Elizabeth A

Abstract excerpt

A number of alanine and more conservative mutants of residues in the fourth domain of thrombomodulin (TM) were prepared and assayed for protein C activation and for thrombin binding. Several of the alanine mutations appeared to cause misfolding or structural defects as assessed by poor expression...

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Share to Epidermal Growth Factor
Share to Mutagenesis, Site-Directed
Share to Nuclear Magnetic Resonance, Biomolecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Sequence Homology, Amino Acid

Share to Spectrometry, Fluorescence

Share to Surface Plasmon Resonance

Share to Thrombin

Share to Thrombomodulin

Source

Open in PubMed Open full text

Identifiers

PMID: 18803401
DOI: 10.1021/bi8008278
PMCID: PMC2630536

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18803401-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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