Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregation.

Molecular and cellular biology - 1 Jul 1993

Payne W E, Fitzgerald-Hayes M

Abstract excerpt

We identified a putative Saccharomyces cerevisiae homolog of a phosphoinositide-specific phospholipase C (PI-PLC) gene, PLC1, which encodes a protein most similar to the delta class of PI-PLC enzymes. The PLC1 gene was isolated during a study of yeast strains that exhibit defects in chromosome segregation. plc1-1 cells showed a 10-fold increase in aberrant chromosome segregation compared with the wild type....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to Genes, Fungal

Share to Molecular Sequence Data

Share to Mutation

Share to Phenotype

Share to Restriction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 8391635
DOI: 10.1128/mcb.13.7.4351-4364.1993
PMCID: PMC359995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregation.PMID 8391635Read ↗

Genetic evidence for a role of phospholipase C at the budding yeast kinetochore.Semantic proximity Read ↗

Isolation and characterization of temperature-sensitive plc1 mutants of the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

CDP1, a novel Saccharomyces cerevisiae gene required for proper nuclear division and chromosome segregation.Semantic proximity Read ↗

Plc1p is required for proper chromatin structure and activity of the kinetochore in Saccharomyces cerevisiae by facilitating recruitment of the RSC complex.Semantic proximity Read ↗

An essential function of a phosphoinositide-specific phospholipase C is relieved by inhibition of a cyclin-dependent protein kinase in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Growth of a mutant defective in a putative phosphoinositide-specific phospholipase C of Schizosaccharomyces pombe is restored by low concentrations of phosphate and inositol.Semantic proximity Read ↗

Regulation of yeast chromosome segregation by Ipl1 protein kinase and type 1 protein phosphatase.Semantic proximity Read ↗

Yeast phospholipase C is required for normal acetyl-CoA homeostasis and global histone acetylation.Semantic proximity Read ↗

PAT1, an evolutionarily conserved acetyltransferase homologue, is required for multiple steps in the cell cycle.Semantic proximity Read ↗

Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation.Semantic proximity Read ↗

Disruption of a gene encoding phosphatidic acid phosphatase causes abnormal phenotypes in cell growth and abnormal cytokinesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Cak1p protein kinase is required at G1/S and G2/M in the budding yeast cell cycle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.