Article
A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregation.
Molecular and cellular biology - 1 Jul 1993
Payne W E, Fitzgerald-Hayes M
Abstract excerpt
We identified a putative Saccharomyces cerevisiae homolog of a phosphoinositide-specific phospholipase C (PI-PLC) gene, PLC1, which encodes a protein most similar to the delta class of PI-PLC enzymes. The PLC1 gene was isolated during a study of yeast strains that exhibit defects in chromosome segregation. plc1-1 cells showed a 10-fold increase in aberrant chromosome segregation compared with the wild type....
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Calcium
- Chromosomes
- Cloning, Molecular
- DNA, Fungal
- Genes, Fungal
- Humans
- Mitosis
- Molecular Sequence Data
- Mutation
- Phenotype
- Phosphatidylinositol Diacylglycerol-Lyase