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Article

Yeast phospholipase C is required for normal acetyl-CoA homeostasis and global histone acetylation.

The Journal of biological chemistry - 27 Sept 2013

Galdieri Luciano, Chang Jennifer, Mehrotra Swati, Vancura Ales

Abstract excerpt

Phospholipase C (Plc1p) is required for the initial step of inositol polyphosphate (InsP) synthesis, and yeast cells with deletion of the PLC1 gene are completely devoid of any InsPs and display aberrations in transcriptional regulation. Here we show that Plc1p is required for a normal level of histone acetylation; plc1Δ cells that do not synthesize any InsPs display decreased acetylation of bulk histones and...

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Share to Acetyl Coenzyme A
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23913687
DOI: 10.1074/jbc.M113.492348
PMCID: PMC3784712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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